Nocturnal asthma: role of snoring and obstructive sleep apnea. J Clin Invest 1995 95: 1635Ĭhan CS, Woolcock AJ, Sullivan CE. Genetic polymorphisms of the β-2 adrenergic receptor in nocturnal and nonnocturnal asthma. Plasma histamine, epinephrine, cortisol, and leukocyte β-adrenergic receptors in nocturnal asthma. Parasympathetic nervous system in nocturnal asthma. Nocturnal asthma and changes in circulatory epinephrine, histamine and cortisol. Am Rev Respir Dis 1992 146: 905–11īarnes P, FitzGerald G, Brown M, et al. Enhanced production of oxygen radicals in nocturnal asthma. Airways inflammation in nocturnal asthma. Martin RJ, Cicutto LC, Ballard RD, et al. Factors related to the nocturnal worsening of asthma. Comparison of normal and asthmatic circadian rhythms in peak expiratory flow rate. Ein neues therapieprinzip bei nachtlichen asthma. Deaths from asthma in Victoria: a 12-month study. That is, instead of viewing a patient as being in homeostasis and administering medication in equally divided doses, treatment should be focused on delivering higher doses of medication at the time of day when the disease process is at its most severe. The second treatment option focuses on direct pharmacological approaches using the new concept of chronotherapy. These include treatment of sleep apnoea, if it exists in an asthma patient, high-gastroesophageal reflux and rhinosinusitis, as well as inspiratory muscle training. First, there are indirect interventions which can improve nocturnal asthma. Therapy should be approached from 2 viewpoints. ![]() However, in the asthmatic patient, these day to night alterations in circadian rhythm produce increased airway inflammation and worsening of asthma. There are many naturally occurring circadian rhythms, which for the normal individual have only a minor effect on lung function. ![]() The aetiology of this process is multifactorial and interactive. The majority of patients with asthma have nocturnal worsening in lung function. Nocturnal asthma is an important part of asthma and must be considered in regard to therapy.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |